Overview of Selected Chemical Compounds and Intermediates
Overview of Selected Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This really is an impurity connected with bortezomib, a proteasome inhibitor Utilized in the treatment of multiple myeloma. Its synthesis or review is critical for making certain the purity and safety from the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor from the synthesis of abiraterone acetate, a drug Utilized in the therapy of prostate most cancers by inhibiting androgen output.
Imatinib Intermediate (CAS NO. 152460-ten-1): A vital compound from the synthesis of imatinib, a drug that targets certain kinds of most cancers, together with Long-term myelogenous leukemia (CML).
Docetaxel Intermediate: A compound used in the synthesis of docetaxel, a chemotherapy medication that treats many cancers for example breast, lung, and prostate most cancers.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): They're intermediates in the synthesis of gemcitabine, an anti-cancer drug. Their analyze is vital for optimizing the production approach and making sure large purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is employed to take care of breast most cancers, and these intermediates are involved in its output.
Fulvestrant Intermediates: Fulvestrant is really an estrogen receptor antagonist Employed in the remedy of breast most cancers. Many intermediates help in the synthesis of this drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug successful in dealing with cancers which include ovarian, breast, and lung 5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid most cancers.
three. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug used in the cure of colorectal cancer and small cell lung cancer.
3-Amino-1-hydroxyadamantane (CAS 702-82-9): This compound is involved in the synthesis of adamantane derivatives, which have a variety of apps, together with antiviral properties.
Vildagliptin Intermediates: Used in the production of vildagliptin, an oral drug for type 2 diabetic issues that inhibits the enzyme DPP-four to control blood sugar concentrations.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-1): This compound is involved with the synthesis of varied gluconic acid derivatives, 4-[2-(2-Amino-4 which might be Utilized in foodstuff, pharmaceutical, and industrial apps.
Canagliflozin Intermediate 2: A precursor inside the synthesis of canagliflozin, a medication applied to control variety 2 diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).